Protein S (Free)
31.13
2.7 mL sodium citrate tube (light blue)
1.8 ml paediatric sodium citrate tube (light blue)
Haematology
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67 – 135% (males)
56 – 135% (females)
In plasma, protein S circulates both free (~40%) and in a complex with C4b binding protein (~60%). Only the free form of protein S can function as an anticoagulant. Protein S levels may be reduced due to a congenital deficiency, an acquired decrease in the protein level (e.g. vitamin K deficiency, liver disease or warfarin therapy), or a shift of free protein to the bound form during an acute phase response with elevated C4b binding protein. A congenital deficiency in protein S may lead to a recurrent thrombotic tendency
PROSF
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