Methotrexate
46.63
N/A
Plain Red top tube ONLY. Do not use gel tubes for this assay.
Frozen
Biochemistry
Mon - Sun, 24hrs
3 hours
Cobas Pro ARK
umol/L
It is vital to correlate the measured level with the specific methotrexate protocol being used
Major toxicities that can result from high plasma/serum levels include myelosuppression, mucosistis and nephrotoxicity.
Mucositis and bone marrow suppression are directly influenced by the dose of Methotrexate given
and the length of time it remains in the blood.
As a guide, clearance is defined as adequate with plasma/serum concentrations of:
<10 umol/L at 24 hrs
<0.5 umol/L at 48 hrs
< 0.05 umol/L at 72 hrs.
20%
0.2 mL plasma or serum.
METX
$METX
