Laboratory Test Reference Guide

Laboratory Information

Test Name

Infectious mononucleosis (screen)

Synonyms

Glandular fever screen
Monospot

External Price (excl. GST)

7

Specimen Collection

Adult Specimen

5 mL blood Plain tube (red) or EDTA tube (purple).

Pre Testing Requirements

A CBC with differential is an essential component of this test. Please ensure one is ordered at time of collection.

Instructions for Referral to Waikato Lab

Aliquot instructions

500uL serum or plasma

Aliquot Transport

Send at 4°C

Test Information

Department

Haematology

Test Availability

Mon - Sun, 24hrs

Laboratory Turnaround Time

2 hrs

Diagnostic Use Or Instructions

Infectious mononucleosis (IM) is an acute herpes viral infection caused by the Epstein-Barr virus (EBV). The peak incidence is between 15 and 19 years of age.

Interpretation

A positive IM screen test indicates the presence of the heterophile antibody and is consistent with Infectious Mononucleosis (Glandular Fever). During the acute phase of the illness, IM heterophile antibodies (primarily of the IgM class) appear in 80-90% of cases. IM antibodies are usually demonstrable 1-12 weeks after the onset of the illness, but have been shown to persist for up to a year.A review of the blood film should also reveal reactive lymphocytes which are variable in size and appearance and show deeply basophilic cytoplasm (Infectious Mononucleosis Cells).The results of the  IM screen test must be part of other clinical and diagnostic results. Other disease states can be confused with or mimic infectious mononucleosis and must be differentiated from IM.

Minimum Volume

1 mL blood Plain tube (red) or EDTA tube (purple).

Electronic Information

Registration Code

IMS

HL7 mapping code

$IMS

LOINC Code

31418-7