ERBB2 FFPE FISH
Her2 FFPE FISH
Her2/Neu
203.23
Histology referral required
One H&E stained slide and 3-4 unprocessed FFPE slides. The H&E slide must be assessed by a pathologist prior to receipt, and appropriate areas for FISH analysis should be clearly marked.
Only tissue preserved in neutral buffered formalin and paraffin embedded is suitable for use. NB: Samples de-calcified in Formic acid are not suitable for FISH as this process affects the integrity of the DNA. Tissue specimens should be cut into sections of 4-6µm.
In slide-holders at ambient temperature.
Cytogenetics
7 days
Fluorescence in situ hybridisation (FISH) on fixed formulin paraffin embedded tissue (FFPE) slides using a probe specific to the ERBB2 (Her2) locus and a chromosome 17 control probe.
Patients with HER2 (ERBB2) gene amplification are eligible for treatment with trastuzumab (Herceptin®), which targets HER2 (ERBB2)and has proved remarkably effective in patients with a tumour over-expressing the protein, in both metastatic and adjuvant settings.
Exam C_FFPE_ERBB2
$C_FFPE_ERBB2
