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Laboratory Test Reference Guide

Laboratory Information

Test Name

Thyroid Antibodies

Synonyms

microsomal antibodies
TPO antibodies
thyroglobulin antibodies
thyroid peroxidase antibodies

Specimen Collection

Adult Specimen

5 mL blood in gold tube or 0.5mL separated serum.

Instructions for Referral to Waikato Lab

Aliquot Transport

fridge

Test Information

Department

Biochemistry

Test Availability

Mon - Fri, 0800 - 1630 excl. Public Holidays

Laboratory Turnaround Time

7 days.

Method

Electrochemiluminescent Immunoassay

Unit of measurement

IU/mL

Reference interval

Thyroid Peroxidase antibodies <35 IU/mL

Uncertainty of measurement

Anti-TPO <15%

Additional Information

Previously, Anti-TG antibodies and anti-TPO antibodies were measured. During March 2017, Anti-TG antibodies were discontinued.

Anti-TPO antibodies offer better performance than anti-TG antibodies for detecting the presence of auto-immune thyroid disease. The only indication for measuring anti-TG antibodies is to check for assay interference when Thyroglobulin (TG) is measured. Thyroglobulin is mainly used as a tumour marker in the follow-up of patients with thyroid cancer. Anti-TG antibodies are present in about 25% of patients with thyroid cancer and can interfere with the TG assay, causing a falsely low result.  A specific assay (Roche), validated for TG measurement is required. Anti-TG  results are assay specific, with large variation seen between assays, which may cause confusion with interpretation of the TG result.

Minimum Volume

0.5 mL serum

Electronic Information

Registration Code

THYGR

HL7 mapping code

$THYGR